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IHC experiments to detect PEG were conducted to further examine the relationship between the administration of Jintrolong® and the development of vacuolation hinein the CP. As shown in Figure 4, no PEG staining was detected hinein the brain CP rein animals of the control group (Figures 4A–C) or the 0.3 mg/kg group (Figures 4D–F). However, positive anti-PEG was observed rein animals at 1 Magnesium/kg (Figure 4G) and with an even stronger staining signal at 3 mg/kg (Figure 4J).
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It is necessary to periodically change the injection area hinein order to avoid localized atrophy of subcutaneous fat.
hinein order to predict the safety rein patients treated with Jintrolong®, we compared the monkey AUC and Cmax at the NOAEL dose (3 mg/kg/week) with the human AUC and Cmax at the clinical dose (0.2 Magnesium/kg/week) rein pediatric GHD patients to generate a safety margin.
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To predict how long it might take for CP vacuolation at 3 mg/kg to achieve complete recovery, the relative number and size of vacuoles in the pathology slides were quantitatively analyzed by the Halo AI tissue typing Anlage. The quantitative evaluation data are roughly consistent with the semi-quantitative evaluation of pathologists.
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Avoid drinking alcohol if you have short bowel syndrome. Alcohol can irritate your stomach and could make your condition worse.
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The drug is not recommended for patients with brain tumors. The therapy should Beryllium stopped if signs of cancer are detected.
Comparison between groups was performed using the mixed-effects model. The factors associated with ΔHT-SDS, ΔHV, and ΔPAH hinein response to GH treatment were determined rein separate multivariate linear regression analyses.
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